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What is QHALER?

Qhaler, is an inhaler device that enables to administer dry powder drug into airways and lungs via mouth in asthma and COPD. It helps to resolve symptoms of disease.



HISTORY OF INHALERS

Inhalation, the method of drug administration via respiratory tract and airways, has an important place in treatment of lung diseases such as asthma and COPD. Inhaler devices have a 200-year history and they are still in use. Inhaler was invented during initial period of industrial revolution and was accepted as a very important and great invention. Inhaler devices have undergone important developments and modifications since its introduction. They were modernized and have become easy-to-use.
When we look at the ancient times, healing and refreshing effects of tobacco and similar herbs were discovered almost 2000 years ago in America. These plants were used in treatment of respiratory disorders by pipe-like tubes which were found and manually shaped by Lake Valencia.

South America tobacco pipes, 2000 years ago

The word “inhaler” was used by British physician John Mudge for the first time. In 1778, John Mudge adopted a tin tankard into a inhalation device and used it with opium plant for treating cough and published a picture of inhaler device for the first time.

The first inhaler device made by tin tankard. John Rudge manufactured it in 1778
It is the first inhaler device that enables patients inhale the drug with the aid of pressurized spraying into air. In addition, Dr. Sales Girons invented the first pressurized inhaler device in 1858 and won ‘Paris Academy of Science’ award.

The first pressurized inhaler device, 1858
The first ceramic coated Nelson inhaler device developed by the company named S. Maw & Son in 1865 and published in ‘the Lancet’. It is still used in treatment under different names with small modifications.

Nelson inhaler, 1865
Besides development of inhaler devices used for treatment of respiratory disorders, different and interesting methods were also used during that period. The first one was named ‘inhaler pillow’ and aimed inhalation of drug placed into a pillow during whole night. Another one used asthma cigarettes in treatment of asthma between 1800-1985. Asthma cigarettes containing various herbal extracts have been used in treatment of lung diseases until recently. Found for the first time in 1890 and published in Scientific American, oxygen bar method enables patients to inhale purified oxygen. Invention of oxygen bar aimed to provide fresh air in order to improve lung functions of patients.
  
Reference: Sanders.M. Inhalation therapy: an historical review, Primary Care Respiratory Journal, 2007;16[2]:71-81.


HOW TO USE QHALER?


ASTHMA

ASTHMA

ASTHMA

COPD

COPD

Symptoms of COPD 

COPD mostly becomes evident after 40 years of age. 

Mild COPD, is long-term cough and phlegm discharge. These symptoms are mostly disregarded by patients and might have been started years before airflow limitation.

In moderate COPD, airflow limitation becomes evident and patients experience shortness of breathing that affects their daily life. During this stage, patients seek medical aid and diagnosed with COPD.  

In severe COPD, shortness of breathing is severe during daily work, fatigue occurs, and sleep becomes irregular due to nocturnal breathing problems.

In very severe COPD, shortness of breathing is evident even in the sitting position, walking is difficult and daily activities (working etc) are severely limited.

The most common symptoms of COPD;

  • Long-term cough: The first symptom of COPD is mostly cough, patients tend to connect it to smoking and disregard it.
  • Shortness of breathing: is the most important symptom for seeking medical aid.
  • Long-term phlegm discharge: is generally accompany to cough. It is white-grey coloured, viscose and sticky.
  • Wheezing and chest tightness: wheezing and chest tightness are not specific to COPD and may vary day to day.
  • Infection: Bacterial and viral infections are frequent in COPD patients.1-3

References:

1.http://www.solunum.org.tr/TusadData/userfiles/file/KOAH.pdf
2.
http://www.toraks.org.tr/uploadFiles/book/file/232201117745-tani.pdf

3.
http://www.patient.co.uk/health/chronic-obstructive-pulmonary-disease-leaflet

COPD

Diagnosis and treatment of COPD

Diagnosis 

Diagnosis of COPD is based on evaluation of symptoms, patient’s history, physical examination and respiratory function tests. Plain X-ray graphs and blood gas analyses are also among other helpful tests.

Evaluation of symptoms: Long-term cough, phlegm discharge, shortness of breathing, and/or history of exposure to risk factors would suggest COPD. 

History: Each patient suspected COPD should undergo a detailed medical history taking which includes smoking, occupational exposure, pollution, family history, hospitalizations and medications.

Physical examination: Physical examination is not enough for COPD diagnosis. Physical examination reveals no sign or symptoms until the airflow limitation leads to impairment in respiratory functions.

Respiratory function tests: Each patient suspected COPD should undergo respiratory function tests. Respiratory function tests are easy, repeatable and valid way to demonstrate airflow limitation.1,2

References:
1. http://www.toraks.org.tr/uploadFiles/book/file/232201117745-tani.pdf
2. http://www.goldcopd.org/uploads/users/files/GOLD_Pocket_May2512.pdf


Treatment

COPD is preventable and partly treatable disease. Four important approaches in COPD are;

  • Education of patient and relatives, 
  • Reduction of COPD risk factors, 
  • Medical treatment and 
  • Reduction of exacerbations. 


The main goals of treatment are to prevent progression of the disease, to reduce symptoms, to increase exercise capacity and to improve quality of life. 

  • Although prevention of COPD is fundamental, patient education and compliance together with encouragement for an active life style are crucial.
  • One of the most effective step of treatment is quit smoking which is the leading cause of COPD. Besides smoking, occupational exposure may play role in development of COPD, therefore, avoiding exposure may retard loss of respiratory functions.
  • Besides stable drug therapy in COPD, there are alternative options including long-term oxygen treatment, exercise education, and psychological support.

Reference: http://www.toraks.org.tr/uploadFiles/book/file/232201117834-hastaligin_tedavisi.pdf


The difference between COPD and ASTHMA

COPD and asthma may be comorbid conditions in the same person, they have similar symptoms and are long-term, obstructive airway diseases. Both present with airway inflammation, but characteristics of this inflammation are very different in two conditions, eventually their treatment responses are very different. Airflow limitation in asthma may fully relieve spontaneously or on medication, whereas airflow limitation in COPD is not fully reversible and it is progressive when the exposure is continuing.

Reference: Athanazio R. Airway disease: similarities and differences between asthma, COPD and bronchiectasis. CLINICS 2012;67(11):1335-1343.

COPD FAQs (Frequently Asked Questions)

  • How does smoking affect COPD?

Of the daily smokers, 82% started smoking under 18 years of age and 53% started to smoke on daily basis before that age. Smoking is the leading risk factor for development of COPD. It also compromise the response to treatment. Smokers, with or without COPD, have inflammation and thickening of small airways. This increases exacerbations and progression of the disease.

Reference: M.N. Hylkema, et al. KOAH ve astım’da sigara kullanımı. Eur Respir J 2007;29: 438–445.

  • What is the proper time to consult a physician?

If long-term smokers or workers of mine, metallurgy, cement sector have cough and phlegm discharge (without an obvious reason) for at least 3 months and 2 years in a row, they should consult a physician, 

If they have progressive shortness of breathing, they should consult a physician.

Reference: Erdinç M, et al. KOAH ile yaşam. Ankara. Galenos Yayıncılık San.Tic.Ltd.Şti. 2011.20pp.

  • What are the body and breathing exercises for COPD?

Exercise is necessary for proper lung function. Unfortunately, many lung patients afraid of exercise. This is due to the feeling of difficult breathing or fear of getting harm from difficult breathing. But this is not true, feeling of difficult breathing does not hurt lungs. Immobility leads to muscle weakness and reduced lung capacity. Mobile and active life-style improves lung capacity.

Mainly 4 types of exercises are recommended for COPD patients. The intensity of each type of exercise depends on your COPD exercise program structured by your physician.


Stretching exercises: this type of exercises lengthens your muscles and increase elasticity of your body. In addition, these exercises prepare your body to other works and reduce the possibility of muscle injury.

Aerobic exercises: your heart and lungs work during aerobic exercise and their endurance capacity are increased. This, in turn, increases productivity of oxygen consumption and improves your breathing. If you have COPD walking or cycling ergometer are good choices for aerobic exercise.

Strengthening exercises: comprise of muscle work until exhaustion. This type of exercises for upper body may strengthen your respiration muscles.

Breathing exercises for COPD: work outs which enable deeper breathing with a smaller effort. If you have COPD, you may start breathing exercises 3 or 4 times a day, 5 to 10 minutes puffing and diaphragmatic breathing exercises.

References:

1. Erdinç M, et al. KOAH ile yaşam. Ankara. Galenos Yayıncılık San.Tic.Ltd.Şti. 2011.20pp.
2. http://www.webmd.com/lung/copd/copd-and-exercise-breathing-and-exercise-programs-for-copd

  • What are the precautions during using home nebulizer?

Nebulizer is used to administer drugs into airways when the obstruction or difficult breathing is severe. If a nebulizer is recommended:

-Carefully read the instructions of your nebulizer.

-You can use it by a mouth piece or a mask. Prefer mask in case of emergency.

-After you turn on the nebulizer, you should breathe calmly.

-Wash your face after nebulization.

-You should clean your nebulizer up in accordance to instructions. Otherwise, it may be a source of microbes. Before cleaning, be sure that it is not plugged.

-Nebulizer set should be changed in every 15 days or month according to frequency of use.

-Store your nebulizer in a dry room away from direct sunlight. Do not leave your device on downy places (carpet, blanket).

-Nebulization lasts 10 to 15 minutes. If it lasts longer than 20 minutes, call technical service.

-Nebulizer should be preferred only during attacks and should not be used in state of inhaler.

Reference: Erdinç M, et al. KOAH ile yaşam. Ankara. Galenos Yayıncılık San.Tic.Ltd.Şti. 2011.20pp.

  • What are nutritional factors during the course of disease?

-Body weight should be kept close to ideal.

-If excess weight is present; sugar, floury and fatty food should be avoided.

-If the body weight is lower than normal; Protein and fat-rich diet including meat, chicken, fish, egg, cheese, milk should ne preferred.

-If carbon dioxide in blood is high, fatty food rather than carbohydrates should be preferred.

-Meals should be 6 times a day rather than 3 times.

-Adequate amount of fluid should be taken.

Reference: Erdinç M, et al. KOAH ile yaşam. Ankara. Galenos Yayıncılık San.Tic.Ltd.Şti. 2011.20pp.

  • How to avoid COPD?

-The biggest factor in development of COPD is “smoking”. Even if the patient is not a smoker, exposure to cigarette smoke negatively affects disease. The first line precaution is COPD is to quit smoking and stay away from smoking areas.

-Subjects who work in areas of occupational dust and smoke should not smoke, as it increases the risk of COPD. Staying away from smoking is very important in these subjects. Using mask and other protectors are important in such workplaces.

-In rural areas, animal waste and vegetable products should not be used for heating and cooking. Other sources should be chosen.

-Each year, during September to October, influenza vaccination is important to reduce common cold and flu. Pneumonia vaccination is also recommended every 6 years in required individuals.

Reference: Erdinç M, et al. KOAH ile yaşam. Ankara. Galenos Yayıncılık San.Tic.Ltd.Şti. 2011.20pp.

  • Do I have COPD? 

- Are you a smoker?

- Do you have cough?

- Do you discharge phlegm?

- Do you experience trouble in catching your peers? 

- Do you have shortness of breathing?  

If you say YES to these questions, you may have COPD.

Reference: Erdinç M, et al. KOAH ile yaşam. Ankara. Galenos Yayıncılık San.Tic.Ltd.Şti. 2011.20pp.

INSTRUCTIONS VIDEO


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